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TargetCathepsin G
LigandBDBM50312653
Substrate/Competitorn/a
Meas. Tech.ChEMBL_617825
Ki>26000±n/a nM
Citation Lu TMarkotan TBallentine SKGiardino ECSpurlino JCrysler CSBrown KMaryanoff BETomczuk BEDamiano BPShukla UEnd DAndrade-Gordon PBone RFPlayer MR Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif. J Med Chem 53:1843-56 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin G
Name:Cathepsin G
Synonyms:CG
Type:PROTEIN
Mol. Mass.:28860.08
Organism:Homo sapiens (Human)
Description:ChEMBL_1469016
Residue:255
Sequence:
MQPLLLLLAFLLPTGAEAGEIIGGRESRPHSRPYMAYLQIQSPAGQSRCGGFLVREDFVL
TAAHCWGSNINVTLGAHNIQRRENTQQHITARRAIRHPQYNQRTIQNDIMLLQLSRRVRR
NRNVNPVALPRAQEGLRPGTLCTVAGWGRVSMRRGTDTLREVQLRVQRDRQCLRIFGSYD
PRRQICVGDRRERKAAFKGDSGGPLLCNNVAHGIVSYGKSSGVPPEVFTRVSSFLPWIRT
TMRSFKLLDQMETPL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50312653
n/a
NameBDBM50312653
Synonyms:1-{N-[2-(Amidinoaminooxy)ethyl]amino}carbonylmethyl-6-chloro-3-[2,2-difluoro-2-phenylethylamino]pyrazinone | CHEMBL1088332
TypeSmall organic molecule
Emp. Form.C17H20ClF2N7O3
Mol. Mass.443.836
SMILES[#7]\[#6](-[#7])=[#7]\[#8]-[#6]-[#6]-[#7]-[#6](=O)-[#6]-n1c(Cl)cnc(-[#7]-[#6]C(F)(F)c2ccccc2)c1=O
Structure
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