| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50312720 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615620 (CHEMBL1104194) |
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| IC50 | 24±n/a nM |
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| Citation |  Schmeck, C; Gielen-Haertwig, H; Vakalopoulos, A; Bischoff, H; Li, V; Wirtz, G; Weber, O Novel tetrahydrochinoline derived CETP inhibitors. Bioorg Med Chem Lett20:1740-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50312720 |
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| n/a |
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| Name | BDBM50312720 |
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| Synonyms: | (S)-3'-((S)-fluoro(4-(trifluoromethyl)phenyl)methyl)-4'-(4-fluorophenyl)-2'-isopropyl-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinolin]-5'-ol | BAY-38-1315 | CHEMBL1086624 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28F5NO |
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| Mol. Mass. | 501.5307 |
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| SMILES | CC(C)c1nc2CC3(CCC3)C[C@H](O)c2c(-c2ccc(F)cc2)c1[C@@H](F)c1ccc(cc1)C(F)(F)F |r| |
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| Structure | 
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