| Reaction Details |
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 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
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| Ligand | BDBM50312728 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615620 (CHEMBL1104194) |
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| IC50 | 70±n/a nM |
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| Citation |  Schmeck, C; Gielen-Haertwig, H; Vakalopoulos, A; Bischoff, H; Li, V; Wirtz, G; Weber, O Novel tetrahydrochinoline derived CETP inhibitors. Bioorg Med Chem Lett20:1740-3 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholesteryl ester transfer protein |
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| Name: | Cholesteryl ester transfer protein |
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| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
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| Type: | Enzyme |
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| Mol. Mass.: | 54751.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11597 |
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| Residue: | 493 |
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| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
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| BDBM50312728 |
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| n/a |
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| Name | BDBM50312728 |
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| Synonyms: | (S)-(2',4'-dicyclopentyl-5'-hydroxy-6',8'-dihydro-5'H-spiro[cyclobutane-1,7'-quinoline]-3'-yl)(4-(trifluoromethyl)phenyl)methanone | CHEMBL1087412 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H34F3NO2 |
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| Mol. Mass. | 497.5917 |
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| SMILES | O[C@H]1CC2(CCC2)Cc2nc(C3CCCC3)c(C(=O)c3ccc(cc3)C(F)(F)F)c(C3CCCC3)c12 |r| |
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| Structure | 
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