| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM50312729 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_615620 (CHEMBL1104194) |
|---|
| IC50 | 70±n/a nM |
|---|
| Citation |  Schmeck, C; Gielen-Haertwig, H; Vakalopoulos, A; Bischoff, H; Li, V; Wirtz, G; Weber, O Novel tetrahydrochinoline derived CETP inhibitors. Bioorg Med Chem Lett20:1740-3 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM50312729 |
|---|
| n/a |
|---|
| Name | BDBM50312729 |
|---|
| Synonyms: | (S)-(4-cyclohexyl-5-hydroxy-2-isopropyl-7,7-dimethyl-5,6,7,8-tetrahydroquinolin-3-yl)(4-(trifluoromethyl)phenyl)methanone | CHEMBL1087413 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H34F3NO2 |
|---|
| Mol. Mass. | 473.5703 |
|---|
| SMILES | CC(C)c1nc2CC(C)(C)C[C@H](O)c2c(C2CCCCC2)c1C(=O)c1ccc(cc1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
