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TargetHistamine H2 Receptor
LigandBDBM50312779
Substrate/Competitorn/a
Meas. Tech.ChEMBL_615848
Ki>10000±n/a nM
Citation Yu MLizarzaburu MBeckmann HConnors RDai KHaller KLi CLiang LLindstrom MMa JMotani AWanska MZhang ALi LMedina JC Identification of piperazine-bisamide GHSR antagonists for the treatment of obesity. Bioorg Med Chem Lett 20:1758-62 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H2 Receptor
Name:Histamine H2 receptor
Synonyms:Gastric receptor I | H2R | HISTAMINE H2 | Histamine H2-Gs alpha S
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:40115.31
Organism:Homo sapiens (Human)
Description:n/a
Residue:359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50312779
n/a
NameBDBM50312779
Synonyms:(S)-(4-(1H-indole-6-carbonyl)-3-methylpiperazin-1-yl)(2'-chlorobiphenyl-4-yl)methanone | CHEMBL1080556
TypeSmall organic molecule
Emp. Form.C27H24ClN3O2
Mol. Mass.457.951
SMILESC[C@H]1CN(CCN1C(=O)c1ccc2cc[nH]c2c1)C(=O)c1ccc(cc1)-c1ccccc1Cl |r|
Structure
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