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TargetSphingosine 1-phosphate receptor 1
LigandBDBM50313353
Substrate/Competitorn/a
Meas. Tech.ChEMBL_617125 (CHEMBL1101383)
EC50 6±n/a nM
Citation Crosignani, SBombrun, ACovini, DMaio, MMarin, DQuattropani, ASwinnen, DSimpson, DSauer, WFrançon, BMartin, TCambet, YNichols, AMartinou, IBurgat-Charvillon, FRivron, DDonini, CSchott, OEligert, VNovo-Perez, LVitte, PAArrighi, JF Discovery of a novel series of potent S1P1 agonists. Bioorg Med Chem Lett20:1516-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sphingosine 1-phosphate receptor 1
Name:Sphingosine 1-phosphate receptor 1
Synonyms:CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:Enzyme
Mol. Mass.:42836.02
Organism:Homo sapiens (Human)
Description:P21453
Residue:382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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  Blast E-value cutoff:
BDBM50313353
n/a
NameBDBM50313353
Synonyms:6-(cyclohexyl(cyclopropylmethyl)amino)-N-(6-methyl-1H-indazol-5-yl)pyrimidine-4-carboxamide | CHEMBL1080382 | US9150519, 1-47
TypeSmall organic molecule
Emp. Form.C23H28N6O
Mol. Mass.404.508
SMILESCc1cc2[nH]ncc2cc1NC(=O)c1cc(ncn1)N(CC1CC1)C1CCCCC1
Structure
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