Ki Summary

Reaction Details

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Target

Sphingosine 1-phosphate receptor 5

Ligand

BDBM50313325

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_617127 (CHEMBL1101385)

EC50

258±n/a nM

Citation

Crosignani, S; Bombrun, A; Covini, D; Maio, M; Marin, D; Quattropani, A; Swinnen, D; Simpson, D; Sauer, W; Françon, B; Martin, T; Cambet, Y; Nichols, A; Martinou, I; Burgat-Charvillon, F; Rivron, D; Donini, C; Schott, O; Eligert, V; Novo-Perez, L; Vitte, PA; Arrighi, JF Discovery of a novel series of potent S1P1 agonists. Bioorg Med Chem Lett20:1516-9 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Sphingosine 1-phosphate receptor 5

Name:

Sphingosine 1-phosphate receptor 5

Synonyms:

EDG8 | Endothelial differentiation sphingolipid G-protein-coupled receptor 8 | S1P5 | S1PR5 | S1PR5_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-8

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

41796.42

Organism:

Homo sapiens (Human)

Description:

n/a

Residue:

398

Sequence:

MESGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLV
LGRHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALT
ASVLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLD
ACSTVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRA
RRKPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSL
LNPIIYTLTNRDLRHALLRLVCCGRHSCGRDPSGSQQSASAAEASGGLRRCLPPGLDGSF
SGSERSSPQRDGLDTSGSTGSPGAPTAARTLVSEPAAD

BDBM50313325

n/a

Name

BDBM50313325

Synonyms:

6-(Cyclohexylamino)-N-(4-hydroxy-2-methylphenyl)pyrimidine-4-carboxamide | CHEMBL1081654 | US9150519, 1-1

Type

Small organic molecule

Emp. Form.

C18H22N4O2

Mol. Mass.

326.3929

SMILES

Cc1cc(O)ccc1NC(=O)c1cc(NC2CCCCC2)ncn1

Structure