| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Sodium/glucose cotransporter 1 |
|---|
| Ligand | BDBM50313370 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_617326 (CHEMBL1100948) |
|---|
| IC50 | 5600±n/a nM |
|---|
| Citation |  Robinson, RP; Mascitti, V; Boustany-Kari, CM; Carr, CL; Foley, PM; Kimoto, E; Leininger, MT; Lowe, A; Klenotic, MK; Macdonald, JI; Maguire, RJ; Masterson, VM; Maurer, TS; Miao, Z; Patel, JD; Préville, C; Reese, MR; She, L; Steppan, CM; Thuma, BA; Zhu, T C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization. Bioorg Med Chem Lett20:1569-72 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Sodium/glucose cotransporter 1 |
|---|
| Name: | Sodium/glucose cotransporter 1 |
|---|
| Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 73503.78 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P13866 |
|---|
| Residue: | 664 |
|---|
| Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
|
|
|
|---|
| BDBM50313370 |
|---|
| n/a |
|---|
| Name | BDBM50313370 |
|---|
| Synonyms: | (6S,7R,8R,9S)-6-(4-chloro-3-(4-ethoxybenzyl)phenyl)-2,5-dioxaspiro[3.5]nonane-7,8,9-triol | CHEMBL1091476 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25ClO6 |
|---|
| Mol. Mass. | 420.883 |
|---|
| SMILES | CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2OC3(COC3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
