Reaction Details |
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Target | Sodium/glucose cotransporter 2 |
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Ligand | BDBM50313378 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_617327 (CHEMBL1101142) |
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IC50 | 140±n/a nM |
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Citation | Robinson, RP; Mascitti, V; Boustany-Kari, CM; Carr, CL; Foley, PM; Kimoto, E; Leininger, MT; Lowe, A; Klenotic, MK; Macdonald, JI; Maguire, RJ; Masterson, VM; Maurer, TS; Miao, Z; Patel, JD; Préville, C; Reese, MR; She, L; Steppan, CM; Thuma, BA; Zhu, T C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization. Bioorg Med Chem Lett20:1569-72 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 2 |
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Name: | Sodium/glucose cotransporter 2 |
Synonyms: | Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2 |
Type: | Protein |
Mol. Mass.: | 72902.00 |
Organism: | Homo sapiens (Human) |
Description: | P31639 |
Residue: | 672 |
Sequence: | MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM50313378 |
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n/a |
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Name | BDBM50313378 |
Synonyms: | (2R,3S,4S,5R,6S)-6-(4-chloro-3-(4-methoxybenzyl)phenyl)-2-(hydroxymethyl)-5-methoxytetrahydro-2H-pyran-3,4-diol | CHEMBL1083834 |
Type | Small organic molecule |
Emp. Form. | C21H25ClO6 |
Mol. Mass. | 408.873 |
SMILES | CO[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1c1ccc(Cl)c(Cc2ccc(OC)cc2)c1 |r| |
Structure |
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