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TargetSodium/glucose cotransporter 2
LigandBDBM50313375
Substrate/Competitorn/a
Meas. Tech.ChEMBL_617327 (CHEMBL1101142)
IC50 7.9±n/a nM
Citation Robinson, RPMascitti, VBoustany-Kari, CMCarr, CLFoley, PMKimoto, ELeininger, MTLowe, AKlenotic, MKMacdonald, JIMaguire, RJMasterson, VMMaurer, TSMiao, ZPatel, JDPréville, CReese, MRShe, LSteppan, CMThuma, BAZhu, T C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization. Bioorg Med Chem Lett20:1569-72 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sodium/glucose cotransporter 2
Name:Sodium/glucose cotransporter 2
Synonyms:Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:Protein
Mol. Mass.:72902.00
Organism:Homo sapiens (Human)
Description:P31639
Residue:672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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  Blast E-value cutoff:
BDBM50313375
n/a
NameBDBM50313375
Synonyms:(5S,6R,7R,8S)-5-(3-(4-methoxybenzyl)-4-methylphenyl)-4-oxaspiro[2.5]octane-6,7,8-triol | CHEMBL1098377
TypeSmall organic molecule
Emp. Form.C22H26O5
Mol. Mass.370.4388
SMILESCOc1ccc(Cc2cc(ccc2C)[C@@H]2OC3(CC3)[C@@H](O)[C@H](O)[C@H]2O)cc1 |r|
Structure
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