| Reaction Details |
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 | Report a problem with these data |
| Target | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Ligand | BDBM50313452 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_617371 (CHEMBL1101882) |
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| IC50 | 8350000±n/a nM |
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| Citation |  Jha, A; Mukherjee, C; Prasad, AK; Parmar, VS; Vadaparti, M; Das, U; De Clercq, E; Balzarini, J; Stables, JP; Shrivastav, A; Sharma, RK; Dimmock, JR Derivatives of aryl amines containing the cytotoxic 1,4-dioxo-2-butenyl pharmacophore. Bioorg Med Chem Lett20:1510-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycylpeptide N-tetradecanoyltransferase 1 |
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| Name: | Glycylpeptide N-tetradecanoyltransferase 1 |
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| Synonyms: | Myristoyl-CoA:protein N-myristoyltransferase (Nmt) | N-myristoyltransferase (NMT1) | NMT | NMT1 | NMT1_HUMAN | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56814.10 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30419 |
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| Residue: | 496 |
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| Sequence: | MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
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| BDBM50313452 |
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| n/a |
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| Name | BDBM50313452 |
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| Synonyms: | (E)-4-oxo-4-(p-tolylamino)but-2-enoic acid | 4-oxo-4-(p-tolylamino)but-2-enoate | CHEMBL1084931 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H11NO3 |
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| Mol. Mass. | 205.2099 |
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| SMILES | Cc1ccc(NC(=O)\C=C\C(O)=O)cc1 |
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| Structure | 
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