Reaction Details |
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Target | Protein kinase C theta type |
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Ligand | BDBM50313582 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_614192 (CHEMBL1105142) |
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IC50 | 1.2±n/a nM |
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Citation | Boschelli, DH; Subrath, J; Niu, C; Wu, B; Wang, Y; Lee, J; Brennan, A; Ho, M; Deng, B; Yang, X; Xu, X; Leung, L; Wang, J; Atherton, J; Chaudhary, D Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors. Bioorg Med Chem Lett20:1965-8 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Protein kinase C theta type |
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Name: | Protein kinase C theta type |
Synonyms: | KPCT_HUMAN | PRKCQ | PRKCT | Protein kinase C theta | Protein kinase C theta type (PRKCQ) | Protein kinase C, PKC; classical/novel | nPKC-theta |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 81878.04 |
Organism: | Homo sapiens (Human) |
Description: | Full-length human PKC theta (Panvera Catalog No. P2996). |
Residue: | 706 |
Sequence: | MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQMYIQKKPTMYPPWDSTF
DAHINKGRVMQIIVKGKNVDLISETTVELYSLAERCRKNNGKTEIWLELKPQGRMLMNAR
YFLEMSDTKDMNEFETEGFFALHQRRGAIKQAKVHHVKCHEFTATFFPQPTFCSVCHEFV
WGLNKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINSRETMFHKERFKIDMPHRFKVYNYK
SPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTKVANLCGINQKLMAEALAMIESTQQ
ARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTPGKREPQGISWESPLDEVDKMCHLP
EPELNKERPSLQIKLKIEDFILHKMLGKGSFGKVFLAEFKKTNQFFAIKALKKDVVLMDD
DVECTMVEKRVLSLAWEHPFLTHMFCTFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSR
ATFYAAEIILGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKTNTFC
GTPDYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPR
WLEKEAKDLLVKLFVREPEKRLGVRGDIRQHPLFREINWEELERKEIDPPFRPKVKSPFD
CSNFDKEFLNEKPRLSFADRALINSMDQNMFRNFSFMNPGMERLIS
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BDBM50313582 |
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n/a |
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Name | BDBM50313582 |
Synonyms: | (E)-4-(4-methyl-1H-indol-5-ylamino)-5-(3-(morpholinomethyl)styryl)nicotinonitrile | CHEMBL1086419 |
Type | Small organic molecule |
Emp. Form. | C28H27N5O |
Mol. Mass. | 449.5469 |
SMILES | Cc1c(Nc2c(\C=C\c3cccc(CN4CCOCC4)c3)cncc2C#N)ccc2[nH]ccc12 |
Structure |
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