Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50313624 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_614439 (CHEMBL1110509) |
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IC50 | 0.09±n/a nM |
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Citation | Morriello, GJ; Mills, SG; Johnson, T; Reibarkh, M; Chicchi, G; DeMartino, J; Kurtz, M; Davies, P; Tsao, KL; Zheng, S; Tong, X; Carlson, E; Townson, K; Tattersall, FD; Wheeldon, A; Boyce, S; Collinson, N; Rupniak, N; Moore, S; DeVita, RJ Substituted fused bicyclic pyrrolizinones as potent, orally bioavailable hNK1 antagonists. Bioorg Med Chem Lett20:2007-12 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50313624 |
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n/a |
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Name | BDBM50313624 |
Synonyms: | (6R,7S,7aR)-1-amino-6-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-7-(4-fluorophenyl)tetrahydro-1H-pyrrolizin-3(2H)-one | CHEMBL1090742 |
Type | Small organic molecule |
Emp. Form. | C23H21F7N2O2 |
Mol. Mass. | 490.4139 |
SMILES | C[C@@H](O[C@H]1CN2[C@@H](C(N)CC2=O)[C@@H]1c1ccc(F)cc1)c1cc(cc(c1)C(F)(F)F)C(F)(F)F |r| |
Structure |
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