Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50313642 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_614520 (CHEMBL1111495) |
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IC50 | 10000±n/a nM |
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Citation | Morphy, R Selectively nonselective kinase inhibition: striking the right balance. J Med Chem53:1413-37 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase |
Type: | Enzyme |
Mol. Mass.: | 21453.99 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human DHFR. |
Residue: | 187 |
Sequence: | MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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BDBM50313642 |
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n/a |
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Name | BDBM50313642 |
Synonyms: | (Z)-5-(2-(naphthalen-1-yl)prop-1-enyl)furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL1080403 |
Type | Small organic molecule |
Emp. Form. | C19H16N4O |
Mol. Mass. | 316.3565 |
SMILES | C\C(=C\c1coc2nc(N)nc(N)c12)c1cccc2ccccc12 |
Structure |
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