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TargetDihydrofolate reductase
LigandBDBM50313642
Substrate/Competitorn/a
Meas. Tech.ChEMBL_614520 (CHEMBL1111495)
IC50 10000±n/a nM
Citation Morphy, R Selectively nonselective kinase inhibition: striking the right balance. J Med Chem53:1413-37 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DHFR | DYR_HUMAN | Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50313642
n/a
NameBDBM50313642
Synonyms:(Z)-5-(2-(naphthalen-1-yl)prop-1-enyl)furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL1080403
TypeSmall organic molecule
Emp. Form.C19H16N4O
Mol. Mass.316.3565
SMILESC\C(=C\c1coc2nc(N)nc(N)c12)c1cccc2ccccc12
Structure
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