| Reaction Details |
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 | Report a problem with these data |
| Target | RAC-beta serine/threonine-protein kinase |
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| Ligand | BDBM25014 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614505 (CHEMBL1111478) |
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| IC50 | 13±n/a nM |
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| Citation |  Morphy, R Selectively nonselective kinase inhibition: striking the right balance. J Med Chem53:1413-37 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RAC-beta serine/threonine-protein kinase |
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| Name: | RAC-beta serine/threonine-protein kinase |
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| Synonyms: | AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta |
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| Type: | Enzyme |
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| Mol. Mass.: | 55766.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 481 |
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| Sequence: | MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAEC
QLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPM
DYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAM
KILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFH
LSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEG
ISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFE
LILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQK
KLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIR
E
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| BDBM25014 |
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| n/a |
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| Name | BDBM25014 |
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| Synonyms: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3R)-piperidin-3-ylmethoxy]-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol | oxadiazole-containing compound, 3h |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27N7O3 |
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| Mol. Mass. | 425.4842 |
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| SMILES | CCn1c(nc2c(ncc(OC[C@@H]3CCCNC3)c12)C#CC(C)(C)O)-c1nonc1N |r| |
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| Structure | 
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