| Reaction Details |
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 | Report a problem with these data |
| Target | Metacaspase-2 |
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| Ligand | BDBM50313778 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_614949 (CHEMBL1116826) |
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| IC50 | 1100±n/a nM |
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| Citation |  Berg, M; Van der Veken, P; Joossens, J; Muthusamy, V; Breugelmans, M; Moss, CX; Rudolf, J; Cos, P; Coombs, GH; Maes, L; Haemers, A; Mottram, JC; Augustyns, K Design and evaluation of Trypanosoma brucei metacaspase inhibitors. Bioorg Med Chem Lett20:2001-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metacaspase-2 |
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| Name: | Metacaspase-2 |
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| Synonyms: | Metacaspase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37791.17 |
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| Organism: | Trypanosoma brucei |
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| Description: | ChEMBL_614949 |
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| Residue: | 347 |
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| Sequence: | MCSLITQLCDAGQLADYVGLGWLNAVSSQPYLVQALGLQPPPRRVDVDAAFRDAEGLHGH
QPWVATPLPGRTVRALFIGINYYGTSAALSGCCNDVKQMLATLQKKGLPINEAVILVDED
NFPGRTDQPTRDNIVRYMAWLVKDAKPGDVLFFHYSGHGTQCKSRGDSDEKYDQCIAPVD
FQKSGCIVDDDIHKLLFSRLPEKVRLTAVFDCCHSGSIMDLPFTYVCSGGEQASGTPHMK
RIREGNDVLGDVMMISGCADEQTSADVKNTATFGTGSTGAGGAATQCITCMLMNNQSLSY
GKLLIETRDMLKRKGFKQVPQLSASKAIDLDQTFSLTEMFSVDRSVQ
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| BDBM50313778 |
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| n/a |
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| Name | BDBM50313778 |
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| Synonyms: | CHEMBL1082043 | benzyl 1-((S)-1-(benzo[d]thiazol-2-yl)-5-guanidino-1-oxopentan-2-ylamino)-3-methyl-1-oxobutan-2-ylcarbamate |
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| Type | Small organic molecule |
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| Emp. Form. | C26H32N6O4S |
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| Mol. Mass. | 524.635 |
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| SMILES | [#6]-[#6](-[#6])-[#6](-[#7]-[#6](=O)-[#8]-[#6]-c1ccccc1)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#6](=O)-c1nc2ccccc2s1 |r| |
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| Structure | 
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