| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50313978 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_615509 |
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| Ki | 8±n/a nM |
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| Citation |  Shen HC; Ding FX; Raghavan S; Deng Q; Luell S; Forrest MJ; Carballo-Jane E; Wilsie LC; Krsmanovic ML; Taggart AK; Wu KK; Wu TJ; Cheng K; Ren N; Cai TQ; Chen Q; Wang J; Wolff MS; Tong X; Holt TG; Waters MG; Hammond ML; Tata JR; Colletti SL Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem 53:2666-70 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50313978 |
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| n/a |
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| Name | BDBM50313978 |
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| Synonyms: | 2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)-2-methylpropanamido)cyclohex-1-enecarboxylic acid | CHEMBL1086656 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N4O5 |
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| Mol. Mass. | 372.3752 |
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| SMILES | CC(Cc1nc(no1)-c1ccc(O)cn1)C(=O)NC1=C(CCCC1)C(O)=O |t:20| |
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| Structure | 
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