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TargetHydroxycarboxylic acid receptor 2
LigandBDBM50313983
Substrate/Competitorn/a
Meas. Tech.ChEMBL_615509
Ki 130±n/a nM
Citation Shen HCDing FXRaghavan SDeng QLuell SForrest MJCarballo-Jane EWilsie LCKrsmanovic MLTaggart AKWu KKWu TJCheng KRen NCai TQChen QWang JWolff MSTong XHolt TGWaters MGHammond MLTata JRColletti SL Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem 53:2666-70 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hydroxycarboxylic acid receptor 2
Name:Hydroxycarboxylic acid receptor 2
Synonyms:G-protein coupled receptor 109A | G-protein coupled receptor HM74A | Hydroxycarboxylic acid receptor 2 | Niacin Receptor GPR109A | Nicotinic acid receptor 1
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41868.22
Organism:Homo sapiens (Human)
Description:Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay.
Residue:363
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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  Blast E-value cutoff:
BDBM50313983
n/a
NameBDBM50313983
Synonyms:2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)-3-methylbutanamido)cyclohex-1-enecarboxylic acid | CHEMBL1084394
TypeSmall organic molecule
Emp. Form.C19H22N4O5
Mol. Mass.386.4018
SMILESCC(C)(CC(=O)NC1=C(CCCC1)C(O)=O)c1nc(no1)-c1ccc(O)cn1 |t:7|
Structure
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