| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
|---|
| Ligand | BDBM50313976 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_615706 (CHEMBL1106879) |
|---|
| EC50 | 4600±n/a nM |
|---|
| Citation |  Shen, HC; Ding, FX; Raghavan, S; Deng, Q; Luell, S; Forrest, MJ; Carballo-Jane, E; Wilsie, LC; Krsmanovic, ML; Taggart, AK; Wu, KK; Wu, TJ; Cheng, K; Ren, N; Cai, TQ; Chen, Q; Wang, J; Wolff, MS; Tong, X; Holt, TG; Waters, MG; Hammond, ML; Tata, JR; Colletti, SL Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate. J Med Chem53:2666-70 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Hydroxycarboxylic acid receptor 2 |
|---|
| Name: | Hydroxycarboxylic acid receptor 2 |
|---|
| Synonyms: | Gpr109 | Gpr109a | Gpr109b | HCAR2_RAT | HM74 nicotinic acid GPCR | Hcar2 | Niacr1 | Pumag |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 41476.06 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_820675 |
|---|
| Residue: | 360 |
|---|
| Sequence: | MSKQNHFLVINGKNCCVFRDENIAKVLPPVLGLEFVFGLLGNGLALWIFCFHLKSWKSSR
IFLFNLAVADFLLIICLPFLTDNYVQNWDWRFGSIPCRVMLFMLAMNRQGSIIFLTVVAV
DRYFRVVHPHHFLNKISNRTAAIISCFLWGITIGLTVHLLYTDMMTRNGDANLCSSFSIC
YTFRWHDAMFLLEFFLPLGIILFCSGRIIWSLRQRQMDRHVKIKRAINFIMVVAIVFVIC
FLPSVAVRIRIFWLLYKHNVRNCDIYSSVDLAFFTTLSFTYMNSMLDPVVYYFSSPSFPN
FFSTCINRCLRRKTLGEPDNNRSTSVELTGDPSTIRSIPGALMTDPSEPGSPPYLASTSR
|
|
|
|---|
| BDBM50313976 |
|---|
| n/a |
|---|
| Name | BDBM50313976 |
|---|
| Synonyms: | 2-({3-[3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl]-2,2-dimethylpropanoyl}-amino)cyclohex-1-ene-1-carboxylic acid | CHEMBL1086657 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H22N4O5 |
|---|
| Mol. Mass. | 386.4018 |
|---|
| SMILES | CC(C)(Cc1nc(no1)-c1ccc(O)cn1)C(=O)NC1=C(CCCC1)C(O)=O |t:21| |
|---|
| Structure | 
|
|---|
Search and Browse
