| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50314125 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_623886 (CHEMBL1105409) |
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| Ki | 300±n/a nM |
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| Citation |  Breuning, A; Degel, B; Schulz, F; Büchold, C; Stempka, M; Machon, U; Heppner, S; Gelhaus, C; Leippe, M; Leyh, M; Kisker, C; Rath, J; Stich, A; Gut, J; Rosenthal, PJ; Schmuck, C; Schirmeister, T Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem53:1951-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50314125 |
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| n/a |
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| Name | BDBM50314125 |
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| Synonyms: | (S,E)-Ethyl 4-((S)-2-(tert-Butoxycarbonylamino)-2-phenylacetamido)-7-oxo-7-(tritylamino)hept-2-enoate | CHEMBL1090281 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H45N3O6 |
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| Mol. Mass. | 675.8125 |
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| SMILES | CCOC(=O)\C=C\[C@H](CCC(=O)NC(c1ccccc1)(c1ccccc1)c1ccccc1)NC(=O)[C@@H](NC(=O)OC(C)(C)C)c1ccccc1 |r| |
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| Structure | 
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