Reaction Details |
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Target | Tyrosine-protein kinase Lyn |
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Ligand | BDBM50314344 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_624375 (CHEMBL1107905) |
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IC50 | 28±n/a nM |
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Citation | Tsou, HR; MacEwan, G; Birnberg, G; Grosu, G; Bursavich, MG; Bard, J; Brooijmans, N; Toral-Barza, L; Hollander, I; Mansour, TS; Ayral-Kaloustian, S; Yu, K Discovery and optimization of 2-(4-substituted-pyrrolo[2,3-b]pyridin-3-yl)methylene-4-hydroxybenzofuran-3(2H)-ones as potent and selective ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR). Bioorg Med Chem Lett20:2321-5 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Lyn |
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Name: | Tyrosine-protein kinase Lyn |
Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
Type: | Protein |
Mol. Mass.: | 58575.92 |
Organism: | Homo sapiens (Human) |
Description: | P07948 |
Residue: | 512 |
Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
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BDBM50314344 |
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n/a |
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Name | BDBM50314344 |
Synonyms: | 4-(3-((4-hydroxy-3-oxobenzofuran-2(3H)-ylidene)methyl)-1-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-N-(2-hydroxyethyl)benzamide | CHEMBL1092754 |
Type | Small organic molecule |
Emp. Form. | C26H21N3O5 |
Mol. Mass. | 455.462 |
SMILES | Cn1cc(\C=C2/Oc3cccc(O)c3C2=O)c2c(ccnc12)-c1ccc(cc1)C(=O)NCCO |
Structure |
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