| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50314405 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624580 (CHEMBL1110629) |
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| EC50 | 13.65±n/a nM |
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| Citation |  Ma, B; Guckian, KM; Lin, EY; Lee, WC; Scott, D; Kumaravel, G; Macdonald, TL; Lynch, KR; Black, C; Chollate, S; Hahm, K; Hetu, G; Jin, P; Luo, Y; Rohde, E; Rossomando, A; Scannevin, R; Wang, J; Yang, C Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorg Med Chem Lett20:2264-9 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50314405 |
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| n/a |
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| Name | BDBM50314405 |
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| Synonyms: | (S)-2-amino-2-((S)-6-octyl-1,2,3,4-tetrahydronaphthalen-2-yl)propyl dihydrogen phosphate | CHEMBL1090758 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H36NO4P |
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| Mol. Mass. | 397.4886 |
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| SMILES | CCCCCCCCc1ccc2C[C@H](CCc2c1)[C@](C)(N)COP(O)(O)=O |r| |
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| Structure | 
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