| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic elongation factor 2 kinase |
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| Ligand | BDBM50314408 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624587 (CHEMBL1111547) |
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| IC50 | 1100±n/a nM |
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| Citation |  Lockman, JW; Reeder, MD; Suzuki, K; Ostanin, K; Hoff, R; Bhoite, L; Austin, H; Baichwal, V; Adam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett20:2283-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic elongation factor 2 kinase |
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| Name: | Eukaryotic elongation factor 2 kinase |
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| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K |
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| Type: | Protein |
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| Mol. Mass.: | 82116.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 725 |
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| Sequence: | MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYY
SNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAV
TGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDV
YFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYN
SNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNL
GVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSP
QVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDN
MASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGR
VCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFC
EKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDY
LLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQ
DEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAW
AQMEE
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| BDBM50314408 |
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| n/a |
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| Name | BDBM50314408 |
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| Synonyms: | 3-amino-4-methyl-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1091709 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H19N3OS |
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| Mol. Mass. | 289.396 |
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| SMILES | Cc1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |
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| Structure | 
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