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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Eukaryotic elongation factor 2 kinase | ||
| Ligand | BDBM50314420 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_624587 (CHEMBL1111547) | ||
| IC50 | 460±n/a nM | ||
| Citation |  Lockman, JW; Reeder, MD; Suzuki, K; Ostanin, K; Hoff, R; Bhoite, L; Austin, H; Baichwal, V; Adam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett20:2283-6 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Eukaryotic elongation factor 2 kinase | |||
| Name: | Eukaryotic elongation factor 2 kinase | ||
| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K | ||
| Type: | Protein | ||
| Mol. Mass.: | 82116.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 725 | ||
| Sequence: |
| ||
| BDBM50314420 | |||
| n/a | |||
| Name | BDBM50314420 | ||
| Synonyms: | 3-amino-4-(3-methylthiophen-2-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1091830 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H21N3OS2 | ||
| Mol. Mass. | 371.52 | ||
| SMILES | Cc1ccsc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(19.42,1.74,;17.96,2.21,;17.48,3.68,;15.94,3.68,;15.47,2.21,;16.72,1.31,;16.72,-.23,;15.39,-1,;14.31,.09,;12.76,.09,;11.67,-1,;11.67,-2.54,;12.77,-3.63,;14.31,-3.63,;15.39,-2.54,;16.72,-3.31,;18.05,-2.55,;19.53,-3.03,;20.44,-1.78,;21.98,-1.79,;22.76,-.45,;22.75,-3.12,;19.53,-.52,;20.01,.94,;18.05,-1,)| | ||
| Structure | 
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