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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Eukaryotic elongation factor 2 kinase | ||
| Ligand | BDBM50314422 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_624587 (CHEMBL1111547) | ||
| IC50 | 990±n/a nM | ||
| Citation |  Lockman, JW; Reeder, MD; Suzuki, K; Ostanin, K; Hoff, R; Bhoite, L; Austin, H; Baichwal, V; Adam Willardsen, J Inhibition of eEF2-K by thieno[2,3-b]pyridine analogues. Bioorg Med Chem Lett20:2283-6 (2010) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Eukaryotic elongation factor 2 kinase | |||
| Name: | Eukaryotic elongation factor 2 kinase | ||
| Synonyms: | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EEF2K | EF2K_HUMAN | Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | Serine/threonine-protein kinase EEF2K | eEF-2 kinase | eEF-2K | ||
| Type: | Protein | ||
| Mol. Mass.: | 82116.99 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | n/a | ||
| Residue: | 725 | ||
| Sequence: |
| ||
| BDBM50314422 | |||
| n/a | |||
| Name | BDBM50314422 | ||
| Synonyms: | 3-amino-4-(1-methyl-1H-pyrrol-2-yl)-5,6,7,8,9,10-hexahydrocycloocta[b]thieno[3,2-e]pyridine-2-carboxamide | CHEMBL1092378 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H22N4OS | ||
| Mol. Mass. | 354.469 | ||
| SMILES | Cn1cccc1-c1c2CCCCCCc2nc2sc(C(N)=O)c(N)c12 |(14.66,-10.94,;16.12,-10.46,;16.59,-8.99,;18.13,-8.99,;18.61,-10.46,;17.37,-11.36,;17.38,-12.9,;16.05,-13.67,;14.96,-12.58,;13.42,-12.58,;12.33,-13.67,;12.33,-15.21,;13.42,-16.3,;14.96,-16.3,;16.04,-15.21,;17.37,-15.98,;18.7,-15.22,;20.18,-15.7,;21.1,-14.45,;22.64,-14.46,;23.41,-13.12,;23.4,-15.79,;20.19,-13.19,;20.67,-11.73,;18.71,-13.67,)| | ||
| Structure | 
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