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Target5-hydroxytryptamine receptor 2B
LigandBDBM50314614
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625152 (CHEMBL1115173)
Ki 1670±n/a nM
Citation Liu, KKLefker, BADombroski, MAChiang, PCornelius, PPatterson, TAZeng, YSantucci, STomlinson, EGibbons, CPMarala, RBrown, JAKong, JXLee, EWerner, WWenzel, ZGiragossian, CChen, HCoffey, SB Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity. Bioorg Med Chem Lett20:2365-9 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 2B
Name:5-hydroxytryptamine receptor 2B
Synonyms:5-HT-2B | 5-HT2B | 5-hydroxytryptamine (serotonin) receptor 2B [Homo sapiens] | 5-hydroxytryptamine receptor 2B (5-HT2B) | 5-hydroxytryptamine receptor 2C (5HT2C) | 5HT2B_HUMAN | HTR2B | Serotonin (5-HT3) receptor | Serotonin 2b (5-HT2b) receptor | Serotonin Receptor 2B
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:54312.47
Organism:Homo sapiens (Human)
Description:Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:481
Sequence:
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
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  Blast E-value cutoff:
BDBM50314614
n/a
NameBDBM50314614
Synonyms:(S)-N-(4-(4,4-dimethylcyclohexyloxy)-2,5-difluorobenzyl)pyrrolidine-2-carboxamide | CHEMBL1091106
TypeSmall organic molecule
Emp. Form.C20H28F2N2O2
Mol. Mass.366.4453
SMILESCC1(C)CCC(CC1)Oc1cc(F)c(CNC(=O)[C@@H]2CCCN2)cc1F |r|
Structure
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