| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50314639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_625334 (CHEMBL1111708) |
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| IC50 | 16±n/a nM |
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| Citation |  Cho, YS; Whitehead, L; Li, J; Chen, CH; Jiang, L; Vögtle, M; Francotte, E; Richert, P; Wagner, T; Traebert, M; Lu, Q; Cao, X; Dumotier, B; Fejzo, J; Rajan, S; Wang, P; Yan-Neale, Y; Shao, W; Atadja, P; Shultz, M Conformational refinement of hydroxamate-based histone deacetylase inhibitors and exploration of 3-piperidin-3-ylindole analogues of dacinostat (LAQ824). J Med Chem53:2952-63 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50314639 |
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| n/a |
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| Name | BDBM50314639 |
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| Synonyms: | (E)-3-{3-Fluoro-4-[3-(2-phenyl-1H-indol-3-yl)piperidin-1-ylmethyl]phenyl}-N-hydroxyacrylamide | CHEMBL1093052 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H28FN3O2 |
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| Mol. Mass. | 469.5499 |
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| SMILES | ONC(=O)\C=C\c1ccc(CN2CCCC(C2)c2c([nH]c3ccccc23)-c2ccccc2)c(F)c1 |
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| Structure | 
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