Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetMitogen-activated protein kinase 14
LigandBDBM50314778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_627007 (CHEMBL1103663)
Ki 0.9±n/a nM
Citation Pettus, LHWurz, RPXu, SHerberich, BHenkle, BLiu, QMcBride, HJMu, SPlant, MHSaris, CJSherman, LWong, LMChmait, SLee, MRMohr, CHsieh, FTasker, AS Discovery and evaluation of 7-alkyl-1,5-bis-aryl-pyrazolopyridinones as highly potent, selective, and orally efficacious inhibitors of p38alpha mitogen-activated protein kinase. J Med Chem53:2973-85 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50314778
n/a
NameBDBM50314778
Synonyms:3-(1-(2-Chlorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo-[3,4-b]pyridin-5-yl)-N-cyclopropyl-4-methylbenzamide | CHEMBL1089456
TypeSmall organic molecule
Emp. Form.C24H21ClN4O2
Mol. Mass.432.902
SMILESCc1ccc(cc1-c1cc2cnn(-c3ccccc3Cl)c2n(C)c1=O)C(=O)NC1CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: