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TargetHistamine H1 receptor
LigandBDBM50315191
Substrate/Competitorn/a
Meas. Tech.ChEMBL_625162 (CHEMBL1115183)
Ki 0.8±n/a nM
Citation Li, BFMoree, WJYu, JCoon, TZamani-Kord, SMalany, SJalali, KWen, JWang, HYang, CHoare, SRPetroski, REMadan, ACrowe, PDBeaton, G Selectivity profiling of novel indene H(1)-antihistamines for the treatment of insomnia. Bioorg Med Chem Lett20:2629-33 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H1 receptor
Name:Histamine H1 receptor
Synonyms:H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:55808.72
Organism:Homo sapiens (Human)
Description:Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
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  Blast E-value cutoff:
BDBM50315191
n/a
NameBDBM50315191
Synonyms:(R)-N,N-dimethyl-2-(3-(1-(thiazol-2-yl)ethyl)-1H-inden-2-yl)ethanamine | CHEMBL1092598
TypeSmall organic molecule
Emp. Form.C18H22N2S
Mol. Mass.298.446
SMILESC[C@H](C1=C(CCN(C)C)Cc2ccccc12)c1nccs1 |r,c:2|
Structure
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