Reaction Details |
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Target | C-X-C chemokine receptor type 4 |
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Ligand | BDBM50315299 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_626229 (CHEMBL1107996) |
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IC50 | 190±n/a nM |
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Citation | Skerlj, RT; Bridger, GJ; Kaller, A; McEachern, EJ; Crawford, JB; Zhou, Y; Atsma, B; Langille, J; Nan, S; Veale, D; Wilson, T; Harwig, C; Hatse, S; Princen, K; De Clercq, E; Schols, D Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem53:3376-88 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-X-C chemokine receptor type 4 |
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Name: | C-X-C chemokine receptor type 4 |
Synonyms: | C-X-C chemokine receptor type 4 | C-X-C chemokine receptor type 4 (CXCR4) | CD_antigen=CD184 | CXC-R4 | CXCR-4 | CXCR4 | CXCR4_HUMAN | FB22 | Fusin | HM89 | LCR1 | LESTR | Leukocyte-derived seven transmembrane domain receptor | NPYRL | SDF-1 receptor | Stromal cell-derived factor 1 receptor |
Type: | Enzyme |
Mol. Mass.: | 39754.61 |
Organism: | Homo sapiens (Human) |
Description: | P61073 |
Residue: | 352 |
Sequence: | MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFLTGIVGNGLVI
LVMGYQKKLRSMTDKYRLHLSVADLLFVITLPFWAVDAVANWYFGNFLCKAVHVIYTVNL
YSSVLILAFISLDRYLAIVHATNSQRPRKLLAEKVVYVGVWIPALLLTIPDFIFANVSEA
DDRYICDRFYPNDLWVVVFQFQHIMVGLILPGIVILSCYCIIISKLSHSKGHQKRKALKT
TVILILAFFACWLPYYIGISIDSFILLEIIKQGCEFENTVHKWISITEALAFFHCCLNPI
LYAFLGAKFKTSAQHALTSVSRGSSLKILSKGKRGGHSSVSTESESSSFHSS
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BDBM50315299 |
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n/a |
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Name | BDBM50315299 |
Synonyms: | CHEMBL1092302 | N1-(1H-Benzo[d]imidazol-2-ylmethyl)-N4-methyl-N1-(5,6,7,8-tetrahydroquinolin-8-yl)butane-1,4-diamine |
Type | Small organic molecule |
Emp. Form. | C22H29N5 |
Mol. Mass. | 363.4992 |
SMILES | CNCCCCN(Cc1nc2ccccc2[nH]1)C1CCCc2cccnc12 |
Structure |
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