| Reaction Details |
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 | Report a problem with these data |
| Target | C-X-C chemokine receptor type 1 |
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| Ligand | BDBM50315303 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_626225 (CHEMBL1107992) |
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| IC50 | >10000±n/a nM |
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| Citation |  Skerlj, RT; Bridger, GJ; Kaller, A; McEachern, EJ; Crawford, JB; Zhou, Y; Atsma, B; Langille, J; Nan, S; Veale, D; Wilson, T; Harwig, C; Hatse, S; Princen, K; De Clercq, E; Schols, D Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem53:3376-88 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-X-C chemokine receptor type 1 |
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| Name: | C-X-C chemokine receptor type 1 |
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| Synonyms: | C-X-C chemokine receptor type 1 (CXCR-1) | C-X-C chemokine receptor type 1 (CXCR1) | CMKAR1 | CXCR1 | CXCR1_HUMAN | IL8RA | Interleukin-8 receptor A | Interleukin-8 receptors, CXCR1/CXCR2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39803.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P25024 |
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| Residue: | 350 |
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| Sequence: | MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
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| BDBM50315303 |
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| n/a |
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| Name | BDBM50315303 |
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| Synonyms: | (S)-N-(2-Pyridinylmethyl)-N'-(1H-benzimidazol-2-ylmethyl)-N'-(5,6,7,8-tetrahydro-8-quinolinyl)-1,4-benzenedimethanamine | CHEMBL1093137 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H32N6 |
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| Mol. Mass. | 488.626 |
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| SMILES | C(NCc1ccccn1)c1ccc(CN(Cc2nc3ccccc3[nH]2)[C@H]2CCCc3cccnc23)cc1 |r| |
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| Structure | 
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