| Reaction Details |
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 | Report a problem with these data |
| Target | Solute carrier family 12 member 5 |
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| Ligand | BDBM50315355 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_625987 (CHEMBL1103506) |
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| IC50 | 790±n/a nM |
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| Citation |  Pégurier, C; Bosman, N; Collart, P; Delporte, ML; Leclercq, K; Lengelé, S; Kanduluru, AK; Meunier, S; Pacico, N; Vadali, LR; Wagner, A; Wolff, C; Provins, L Benzyl prolinate derivatives as novel selective KCC2 blockers. Bioorg Med Chem Lett20:2542-5 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Solute carrier family 12 member 5 |
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| Name: | Solute carrier family 12 member 5 |
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| Synonyms: | Kcc2 | S12A5_RAT | Slc12a5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126249.28 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_818163 |
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| Residue: | 1139 |
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| Sequence: | MSRRFTVTSLPPAASAASADPESRRHSVADPRRLPREDVKGDGNPKESSPFINSTDTEKG
REYDGRNMALFEEEMDTSPMVSSLLSGLANYTNLPQGSKEHEEAENNEGGKKKPVQAPRM
GTFMGVYLPCLQNIFGVILFLRLTWVVGIAGIMESFCMVFICCSCTMLTAISMSAIATNG
VVPAGGSYYMISRSLGPEFGGAVGLCFYLGTTFAGAMYILGTIEILLAYLFPAMAIFKAE
DASGEAAAMLNNMRVYGTCVLTCMATVVFVGVKYVNKFALVFLGCVILSILAIYAGVIKS
AFDPPNFPICLLGNRTLSRHGFDVCAKLAWEGNETVTTRLWGLFCSSRLLNATCDEYFTR
NNVTEIQGIPGAASGLIKENLWSSYLTKGVIVERRGMPSVGLADGTPVDMDHPYVFSDMT
SYFTLLVGIYFPSVTGIMAGSNRSGDLRDAQKSIPTGTILAIATTSAVYISSVVLFGACI
EGVVLRDKFGEAVNGNLVVGTLAWPSPWVIVIGSFFSTCGAGLQSLTGAPRLLQAISRDG
IVPFLQVFGHGKANGEPTWALLLTACICEIGILIASLDEVAPILSMFFLMCYMFVNLACA
VQTLLRTPNWRPRFRYYHWTLSFLGMSLCLALMFICSWYYALVAMLIAGLIYKYIEYRGA
EKEWGDGIRGLSLSAARYALLRLEEGPPHTKNWRPQLLVLVRVDQDQNVVHPQLLSLTSQ
LKAGKGLTIVGSVLEGTFLDNHPQAQRAEESIRRLMEAEKVKGFCQVVISSNLRDGVSHL
IQSGGLGGLQHNTVLVGWPRNWRQKEDHQTWRNFIELVRETTAGHLALLVTKNVSMFPGN
PERFSEGSIDVWWIVHDGGMLMLLPFLLRHHKVWRKCKMRIFTVAQMDDNSIQMKKDLTT
FLYHLRITAEVEVVEMHESDISAYTYEKTLVMEQRSQILKQMHLTKNEREREIQSITDES
RGSIRRKNPANTRLRLNVPEETACDNEEKPEEEVQLIHDQSAPSCPSSSPSPGEEPEGEG
ETDPEKVHLTWTKDKSAAQKNKGPSPVSSEGIKDFFSMKPEWENLNQSNVRRMHTAVRLN
EVIVNKSRDAKLVLLNMPGPPRNRNGDENYMEFLEVLTEQLDRVMLVRGGGREVITIYS
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| BDBM50315355 |
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| n/a |
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| Name | BDBM50315355 |
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| Synonyms: | CHEMBL1090196 | benzyl 1-acetyl-2-(thiophen-3-ylmethyl)pyrrolidine-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C19H21NO3S |
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| Mol. Mass. | 343.44 |
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| SMILES | CC(=O)N1CCCC1(Cc1ccsc1)C(=O)OCc1ccccc1 |
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| Structure | 
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