Reaction Details |
| Report a problem with these data |
Target | Calcitonin gene-related peptide type 1 receptor |
---|
Ligand | BDBM50195956 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_626018 (CHEMBL1106146) |
---|
IC50 | 78±n/a nM |
---|
Citation | Stump, CA; Bell, IM; Bednar, RA; Fay, JF; Gallicchio, SN; Hershey, JC; Jelley, R; Kreatsoulas, C; Moore, EL; Mosser, SD; Quigley, AG; Roller, SA; Salvatore, CA; Sharik, SS; Theberge, CR; Zartman, CB; Kane, SA; Graham, SL; Selnick, HG; Vacca, JP; Williams, TM Identification of potent, highly constrained CGRP receptor antagonists. Bioorg Med Chem Lett20:2572-6 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Calcitonin gene-related peptide type 1 receptor |
---|
Name: | Calcitonin gene-related peptide type 1 receptor |
Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52980.45 |
Organism: | Homo sapiens (Human) |
Description: | Q16602 |
Residue: | 461 |
Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
BDBM50195956 |
---|
n/a |
---|
Name | BDBM50195956 |
Synonyms: | (R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide | CHEMBL223156 | N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl]-2-[2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-1-yl]acetamide |
Type | Small organic molecule |
Emp. Form. | C26H22N6O4 |
Mol. Mass. | 482.4907 |
SMILES | CN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4n(-c4ccccn4)c3=O)cc2C1 |r| |
Structure |
|