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TargetCalcitonin gene-related peptide type 1 receptor
LigandBDBM50195956
Substrate/Competitorn/a
Meas. Tech.ChEMBL_626018 (CHEMBL1106146)
IC50 78±n/a nM
Citation Stump, CABell, IMBednar, RAFay, JFGallicchio, SNHershey, JCJelley, RKreatsoulas, CMoore, ELMosser, SDQuigley, AGRoller, SASalvatore, CASharik, SSTheberge, CRZartman, CBKane, SAGraham, SLSelnick, HGVacca, JPWilliams, TM Identification of potent, highly constrained CGRP receptor antagonists. Bioorg Med Chem Lett20:2572-6 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Calcitonin gene-related peptide type 1 receptor
Name:Calcitonin gene-related peptide type 1 receptor
Synonyms:Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:52980.45
Organism:Homo sapiens (Human)
Description:Q16602
Residue:461
Sequence:
MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
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  Blast E-value cutoff:
BDBM50195956
n/a
NameBDBM50195956
Synonyms:(R)-N-(3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl)-2-(2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamide | CHEMBL223156 | N-[(4R)-3-methyl-2,5-dioxo-1',3'-dihydrospiro[imidazolidine-4,2'-indene]-5'-yl]-2-[2-oxo-3-(pyridin-2-yl)-2,3-dihydro-1H-1,3-benzodiazol-1-yl]acetamide
TypeSmall organic molecule
Emp. Form.C26H22N6O4
Mol. Mass.482.4907
SMILESCN1C(=O)NC(=O)[C@]11Cc2ccc(NC(=O)Cn3c4ccccc4n(-c4ccccn4)c3=O)cc2C1 |r|
Structure
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