Reaction Details |
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Target | Sodium/glucose cotransporter 1 |
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Ligand | BDBM50315426 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_626548 (CHEMBL1108921) |
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IC50 | 3990±n/a nM |
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Citation | Kakinuma, H; Oi, T; Hashimoto-Tsuchiya, Y; Arai, M; Kawakita, Y; Fukasawa, Y; Iida, I; Hagima, N; Takeuchi, H; Chino, Y; Asami, J; Okumura-Kitajima, L; Io, F; Yamamoto, D; Miyata, N; Takahashi, T; Uchida, S; Yamamoto, K (1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatment. J Med Chem53:3247-61 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sodium/glucose cotransporter 1 |
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Name: | Sodium/glucose cotransporter 1 |
Synonyms: | High affinity sodium-glucose cotransporter | NAGT | Na(+)/glucose cotransporter 1 | SC5A1_HUMAN | SGLT1 | SLC5A1 | Sodium-dependent glucose cotransporter 1 (SGLT1) | Sodium/glucose cotransporter 1 | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 1 |
Type: | Protein |
Mol. Mass.: | 73503.78 |
Organism: | Homo sapiens (Human) |
Description: | P13866 |
Residue: | 664 |
Sequence: | MDSSTWSPKTTAVTRPVETHELIRNAADISIIVIYFVVVMAVGLWAMFSTNRGTVGGFFL
AGRSMVWWPIGASLFASNIGSGHFVGLAGTGAASGIAIGGFEWNALVLVVVLGWLFVPIY
IKAGVVTMPEYLRKRFGGQRIQVYLSLLSLLLYIFTKISADIFSGAIFINLALGLNLYLA
IFLLLAITALYTITGGLAAVIYTDTLQTVIMLVGSLILTGFAFHEVGGYDAFMEKYMKAI
PTIVSDGNTTFQEKCYTPRADSFHIFRDPLTGDLPWPGFIFGMSILTLWYWCTDQVIVQR
CLSAKNMSHVKGGCILCGYLKLMPMFIMVMPGMISRILYTEKIACVVPSECEKYCGTKVG
CTNIAYPTLVVELMPNGLRGLMLSVMLASLMSSLTSIFNSASTLFTMDIYAKVRKRASEK
ELMIAGRLFILVLIGISIAWVPIVQSAQSGQLFDYIQSITSYLGPPIAAVFLLAIFWKRV
NEPGAFWGLILGLLIGISRMITEFAYGTGSCMEPSNCPTIICGVHYLYFAIILFAISFIT
IVVISLLTKPIPDVHLYRLCWSLRNSKEERIDLDAEEENIQEGPKETIEIETQVPEKKKG
IFRRAYDLFCGLEQHGAPKMTEEEEKAMKMKMTDTSEKPLWRTVLNVNGIILVTVAVFCH
AYFA
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BDBM50315426 |
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n/a |
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Name | BDBM50315426 |
Synonyms: | (1S)-1,5-Anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol | CHEMBL1093423 |
Type | Small organic molecule |
Emp. Form. | C23H30O6S |
Mol. Mass. | 434.546 |
SMILES | CCOc1ccc(Cc2cc([C@@H]3S[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c(OC)cc2C)cc1 |r| |
Structure |
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