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TargetPoly [ADP-ribose] polymerase 2
LigandBDBM50315779
Substrate/Competitorn/a
Meas. Tech.ChEMBL_626085 (CHEMBL1110690)
Ki 1.5±n/a nM
Citation Penning, TDZhu, GDGong, JThomas, SGandhi, VBLiu, XShi, YKlinghofer, VJohnson, EFPark, CHFry, EHDonawho, CKFrost, DJBuchanan, FGBukofzer, GTRodriguez, LEBontcheva-Diaz, VBouska, JJOsterling, DJOlson, AMMarsh, KCLuo, YGiranda, VL Optimization of phenyl-substituted benzimidazole carboxamide poly(ADP-ribose) polymerase inhibitors: identification of (S)-2-(2-fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide (A-966492), a highly potent and efficacious inhibitor. J Med Chem53:3142-53 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Poly [ADP-ribose] polymerase 2
Name:Poly [ADP-ribose] polymerase 2
Synonyms:(ARTD2 or PARP2) | ADPRT2 | ADPRTL2 | PARP2 | PARP2_HUMAN | Poly [ADP-ribose] polymerase 2 (PARP-2) | Poly [ADP-ribose] polymerase 2 (PARP2)
Type:Enzyme
Mol. Mass.:66225.70
Organism:Homo sapiens (Human)
Description:Q9UGN5
Residue:583
Sequence:
MAARRRRSTGGGRARALNESKRVNNGNTAPEDSSPAKKTRRCQRQESKKMPVAGGKANKD
RTEDKQDGMPGRSWASKRVSESVKALLLKGKAPVDPECTAKVGKAHVYCEGNDVYDVMLN
QTNLQFNNNKYYLIQLLEDDAQRNFSVWMRWGRVGKMGQHSLVACSGNLNKAKEIFQKKF
LDKTKNNWEDREKFEKVPGKYDMLQMDYATNTQDEEETKKEESLKSPLKPESQLDLRVQE
LIKLICNVQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCIRAGQHGRALME
ACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKTELQSPEHPLDQ
HYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEKDGEKEAFREDL
HNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYMFGKGIYFADMSSKSANYCFASRLK
NTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAPSSAHFVTLNGSTVPLGP
ASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLKVQFNFLQLW
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  Blast E-value cutoff:
BDBM50315779
n/a
NameBDBM50315779
Synonyms:(S)-2-(2-Fluoro-4-(pyrrolidin-2-yl)phenyl)-1H-benzimidazole-4-carboxamide | CHEMBL1090467
TypeSmall organic molecule
Emp. Form.C18H17FN4O
Mol. Mass.324.3522
SMILESNC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1F)[C@@H]1CCCN1 |r|
Structure
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