| Reaction Details |
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 | Report a problem with these data |
| Target | Sphingosine 1-phosphate receptor 1 |
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| Ligand | BDBM50315813 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_626103 (CHEMBL1111629) |
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| EC50 | 1.1±n/a nM |
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| Citation |  Hamada, M; Nakamura, M; Kiuchi, M; Marukawa, K; Tomatsu, A; Shimano, K; Sato, N; Sugahara, K; Asayama, M; Takagi, K; Adachi, K Removal of sphingosine 1-phosphate receptor-3 (S1P(3)) agonism is essential, but inadequate to obtain immunomodulating 2-aminopropane-1,3-diol S1P(1) agonists with reduced effect on heart rate. J Med Chem53:3154-68 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sphingosine 1-phosphate receptor 1 |
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| Name: | Sphingosine 1-phosphate receptor 1 |
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| Synonyms: | CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 42836.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21453 |
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| Residue: | 382 |
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| Sequence: | MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFII
LENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLR
EGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIM
GWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKN
ISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLA
VLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSH
PQKDEGDNPETIMSSGNVNSSS
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| BDBM50315813 |
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| n/a |
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| Name | BDBM50315813 |
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| Synonyms: | 2-Amino-4-(4'-benzyloxy-2'-fluorobiphenyl-4-yl)-2-(phosphoryloxymethyl)butanol | CHEMBL1092272 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H27FNO6P |
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| Mol. Mass. | 475.4464 |
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| SMILES | NC(CO)(CCc1ccc(cc1)-c1ccc(OCc2ccccc2)cc1F)COP(O)(O)=O |
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| Structure | 
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