| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM50315842 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_624741 (CHEMBL1113417) |
|---|
| IC50 | 81±n/a nM |
|---|
| Citation |  Blanchard, S; William, AD; Lee, AC; Poulsen, A; Teo, EL; Deng, W; Tu, N; Tan, E; Goh, KL; Ong, WC; Ng, CP; Goh, KC; Bonday, Z; Sun, ET Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors. Bioorg Med Chem Lett20:2443-7 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM50315842 |
|---|
| n/a |
|---|
| Name | BDBM50315842 |
|---|
| Synonyms: | 6-(pyrrolidin-1-yl)-3-styryl-1H-indazol-5-amine | CHEMBL1091975 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H20N4 |
|---|
| Mol. Mass. | 304.3889 |
|---|
| SMILES | Nc1cc2c(\C=C\c3ccccc3)n[nH]c2cc1N1CCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
