| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase A |
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| Ligand | BDBM50315851 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_624739 (CHEMBL1113415) |
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| IC50 | 22±n/a nM |
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| Citation |  Blanchard, S; William, AD; Lee, AC; Poulsen, A; Teo, EL; Deng, W; Tu, N; Tan, E; Goh, KL; Ong, WC; Ng, CP; Goh, KC; Bonday, Z; Sun, ET Synthesis and evaluation of alkenyl indazoles as selective Aurora kinase inhibitors. Bioorg Med Chem Lett20:2443-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase A |
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| Name: | Aurora kinase A |
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| Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 45830.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O14965 |
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| Residue: | 403 |
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| Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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| BDBM50315851 |
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| n/a |
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| Name | BDBM50315851 |
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| Synonyms: | 2-phenyl-N-(3-styryl-1H-indazol-5-yl)acetamide | CHEMBL1090912 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H19N3O |
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| Mol. Mass. | 353.4165 |
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| SMILES | O=C(Cc1ccccc1)Nc1ccc2[nH]nc(\C=C\c3ccccc3)c2c1 |
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| Structure | 
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