| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4E |
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| Ligand | BDBM50316312 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_627826 (CHEMBL1117203) |
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| Kd | 4590±n/a nM |
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| Citation |  Jia, Y; Chiu, TL; Amin, EA; Polunovsky, V; Bitterman, PB; Wagner, CR Design, synthesis and evaluation of analogs of initiation factor 4E (eIF4E) cap-binding antagonist Bn7-GMP. Eur J Med Chem45:1304-13 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 4E |
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| Name: | Eukaryotic translation initiation factor 4E |
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| Synonyms: | Eif4e | IF4E_MOUSE |
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| Type: | PROTEIN |
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| Mol. Mass.: | 25051.39 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_627826 |
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| Residue: | 217 |
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| Sequence: | MATVEPETTPTTNPPPAEEEKTESNQEVANPEHYIKHPLQNRWALWFFKNDKSKTWQANL
RLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQ
QRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENRDAVTHIG
RVYKERLGLPPKIVIGYQSHADTATKSGSTTKNRFVV
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| BDBM50316312 |
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| n/a |
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| Name | BDBM50316312 |
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| Synonyms: | ((2R,3S,4R,5R)-5-(2-Amino-7-(4-carboxybenzyl)-6-oxo-1Hpurin-1-ium-9(6H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methylphosphate | CHEMBL1095608 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20N5O10P |
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| Mol. Mass. | 497.3527 |
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| SMILES | Nc1nc2n(c[n+](Cc3ccc(cc3)C(O)=O)c2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)([O-])=O)[C@@H](O)[C@H]1O |r| |
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| Structure | 
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