Reaction Details |
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Target | Phospholipase A2, major isoenzyme |
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Ligand | BDBM50316459 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_630281 (CHEMBL1108229) |
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IC50 | 5330±n/a nM |
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Citation | Meddad-Belhabich, N; Aoun, D; Djimdé, A; Redeuilh, C; Dive, G; Massicot, F; Chau, F; Heymans, F; Lamouri, A Design of new potent and selective secretory phospholipase A(2) inhibitors. 6-Synthesis, structure-activity relationships and molecular modelling of 1-substituted-4-[4,5-dihydro-1,2,4-(4H)-oxadiazol-5-one-3-yl(methyl)]-functionalized aryl piperazin/one/dione derivatives. Bioorg Med Chem18:3588-600 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Phospholipase A2, major isoenzyme |
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Name: | Phospholipase A2, major isoenzyme |
Synonyms: | Group IB phospholipase A2 | PA21B_PIG | PLA2G1B | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 |
Type: | Hydrolase; monomer or homodimer |
Mol. Mass.: | 16279.83 |
Organism: | Sus scrofa (pig) |
Description: | Purchased from Sigma. |
Residue: | 146 |
Sequence: | MKFLVLAVLLTVGAAQEGISSRALWQFRSMIKCAIPGSHPLMDFNNYGCYCGLGGSGTPV
DELDRCCETHDNCYRDAKNLDSCKFLVDNPYTESYSYSCSNTEITCNSKNNACEAFICNC
DRNAAICFSKAPYNKEHKNLDTKKYC
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BDBM50316459 |
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n/a |
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Name | BDBM50316459 |
Synonyms: | 1-[4-(4,5-Dihydro-1,2,4-(4H)-5-oxo-oxadiazol-3-ylmethyl)benzoyl]-4-(4-tetradecyl oxyphenyl)piperazine | CHEMBL1099342 |
Type | Small organic molecule |
Emp. Form. | C34H48N4O4 |
Mol. Mass. | 576.7693 |
SMILES | CCCCCCCCCCCCCCOc1ccc(cc1)N1CCN(CC1)C(=O)c1ccc(Cc2nc(=O)o[nH]2)cc1 |
Structure |
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