| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM50316688 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_632233 (CHEMBL1110095) |
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| Ki | 0.54±n/a nM |
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| Citation |  Childers, WE; Havran, LM; Asselin, M; Bicksler, JJ; Chong, DC; Grosu, GT; Shen, Z; Abou-Gharbia, MA; Bach, AC; Harrison, BL; Kagan, N; Kleintop, T; Magolda, R; Marathias, V; Robichaud, AJ; Sabb, AL; Zhang, MY; Andree, TH; Aschmies, SH; Beyer, C; Comery, TA; Day, M; Grauer, SM; Hughes, ZA; Rosenzweig-Lipson, S; Platt, B; Pulicicchio, C; Smith, DE; Sukoff-Rizzo, SJ; Sullivan, KM; Adedoyin, A; Huselton, C; Hirst, WD The synthesis and biological evaluation of quinolyl-piperazinyl piperidines as potent serotonin 5-HT1A antagonists. J Med Chem53:4066-84 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A |
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| Type: | n/a |
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| Mol. Mass.: | 46122.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 422 |
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| Sequence: | MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADT
RHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGN
SKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RQ
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| BDBM50316688 |
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| n/a |
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| Name | BDBM50316688 |
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| Synonyms: | 8-{4-[4-(6-Methoxyquinolin-8-yl)piperazin-1-yl]piperidin-1-yl}-2-methylquinoline | CHEMBL1096802 |
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| Type | Small organic molecule |
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| Emp. Form. | C29H33N5O |
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| Mol. Mass. | 467.6052 |
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| SMILES | COc1cc(N2CCN(CC2)C2CCN(CC2)c2cccc3ccc(C)nc23)c2ncccc2c1 |
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| Structure | 
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