Reaction Details |
| Report a problem with these data |
Target | Ribosyldihydronicotinamide dehydrogenase [quinone] |
---|
Ligand | BDBM50008356 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_630842 (CHEMBL1109212) |
---|
IC50 | 9±n/a nM |
---|
Citation | Nolan, KA; Humphries, MP; Bryce, RA; Stratford, IJ Imidazoacridin-6-ones as novel inhibitors of the quinone oxidoreductase NQO2. Bioorg Med Chem Lett20:2832-6 (2010) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Ribosyldihydronicotinamide dehydrogenase [quinone] |
---|
Name: | Ribosyldihydronicotinamide dehydrogenase [quinone] |
Synonyms: | Metallothionein-3 | NMOR2 | NQO2 | NQO2_HUMAN | NRH dehydrogenase [quinone] 2 | NRH:quinone oxidoreductase 2 | QR2 | Quinone reductase 2 | Quinone reductase 2 (NQO2) | Ribosyldihydronicotinamide dehydrogenase [quinone] |
Type: | Protein |
Mol. Mass.: | 25917.25 |
Organism: | Homo sapiens (Human) |
Description: | P16083 |
Residue: | 231 |
Sequence: | MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTL
SNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRV
LCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFC
GFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
|
|
|
BDBM50008356 |
---|
n/a |
---|
Name | BDBM50008356 |
Synonyms: | 5-(2-(diethylamino)ethylamino)-8-methoxy-1-methyl-6H-imidazo[4,5,1-de]acridin-6-one | 5-(2-Diethylamino-ethylamino)-8-methoxy-1-methyl-2,10b-diaza-aceanthrylen-6-one(2.0MHCl) | CHEMBL124254 | NSC-637993 |
Type | Small organic molecule |
Emp. Form. | C22H26N4O2 |
Mol. Mass. | 378.4674 |
SMILES | CCN(CC)CCNc1ccc2nc(C)n3c2c1c(=O)c1cc(OC)ccc31 |
Structure |
|