| Reaction Details |
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 | Report a problem with these data |
| Target | Cholinesterase |
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| Ligand | BDBM50317195 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_631312 (CHEMBL1105649) |
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| IC50 | 439±n/a nM |
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| Citation |  Rook, Y; Schmidtke, KU; Gaube, F; Schepmann, D; Wünsch, B; Heilmann, J; Lehmann, J; Winckler, T Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents. J Med Chem53:3611-7 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholinesterase |
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| Name: | Cholinesterase |
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| Synonyms: | BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase |
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| Type: | Enzyme |
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| Mol. Mass.: | 65643.35 |
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| Organism: | Equus caballus (Horse) |
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| Description: | P81908 |
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| Residue: | 574 |
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| Sequence: | EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATK
YANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQT
GTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQK
NIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEAR
NRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLT
DMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPR
VSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYY
FEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNP
NGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAE
REWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
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| BDBM50317195 |
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| n/a |
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| Name | BDBM50317195 |
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| Synonyms: | 2-[4-(beta-Carboline-2-ium-2-ylmethyl)benzyl]-beta-carboline-2-ium dibromide | CHEMBL1094553 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H24N4 |
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| Mol. Mass. | 440.5373 |
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| SMILES | C(c1ccc(C[n+]2ccc3c(c2)[nH]c2ccccc32)cc1)[n+]1ccc2c(c1)[nH]c1ccccc21 |
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| Structure | 
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