| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 1A2 |
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| Ligand | BDBM50317625 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_632900 (CHEMBL1107482) |
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| IC50 | >7500±n/a nM |
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| Citation |  Goodnow, RA; Hicks, A; Sidduri, A; Kowalczyk, A; Dominique, R; Qiao, Q; Lou, JP; Gillespie, P; Fotouhi, N; Tilley, J; Cohen, N; Choudhry, S; Cavallo, G; Tannu, SA; Ventre, JD; Lavelle, D; Tare, NS; Oh, H; Lamb, M; Kurylko, G; Hamid, R; Wright, MB; Pamidimukkala, A; Egan, T; Gubler, U; Hoffman, AF; Wei, X; Li, YL; O'Neil, J; Marcano, R; Pozzani, K; Molinaro, T; Santiago, J; Singer, L; Hargaden, M; Moore, D; Catala, AR; Chao, LC; Hermann, G; Venkat, R; Mancebo, H; Renzetti, LM Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1. J Med Chem53:3502-16 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 1A2 |
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| Name: | Cytochrome P450 1A2 |
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| Synonyms: | CP1A2_HUMAN | CYP1A2 | CYPIA2 | Cholesterol 25-hydroxylase | Cytochrome P(3)450 | Cytochrome P450 1A | Cytochrome P450 1A2 (CYP1A2) | Cytochrome P450 4 | Cytochrome P450-P3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 58423.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P05177 |
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| Residue: | 516 |
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| Sequence: | MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKN
PHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDG
QSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELM
AGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFP
ILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGN
LIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLS
DRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPEL
WEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLE
FSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN
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| BDBM50317625 |
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| n/a |
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| Name | BDBM50317625 |
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| Synonyms: | 4-{2-(2-Carboxyethyl)-3-[6-([1,1',3,1'']terphenyl-5'-yloxy)-hexyl]phenoxy}butyric Acid | CHEMBL1099323 |
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| Type | Small organic molecule |
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| Emp. Form. | C37H40O6 |
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| Mol. Mass. | 580.7099 |
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| SMILES | OC(=O)CCCOc1cccc(CCCCCCOc2cc(cc(c2)-c2ccccc2)-c2ccccc2)c1CCC(O)=O |
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| Structure | 
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