Ki Summary

Reaction Details

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Target

Beta-2 adrenergic receptor

Ligand

BDBM50318160

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_632380 (CHEMBL1115585)

EC50

39±n/a nM

Citation

Baur, F; Beattie, D; Beer, D; Bentley, D; Bradley, M; Bruce, I; Charlton, SJ; Cuenoud, B; Ernst, R; Fairhurst, RA; Faller, B; Farr, D; Keller, T; Fozard, JR; Fullerton, J; Garman, S; Hatto, J; Hayden, C; He, H; Howes, C; Janus, D; Jiang, Z; Lewis, C; Loeuillet-Ritzler, F; Moser, H; Reilly, J; Steward, A; Sykes, D; Tedaldi, L; Trifilieff, A; Tweed, M; Watson, S; Wissler, E; Wyss, D The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist. J Med Chem53:3675-84 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Beta-2 adrenergic receptor

Name:

Beta-2 adrenergic receptor

Synonyms:

Type:

n/a

Mol. Mass.:

46461.69

Organism:

Homo sapiens (Human)

Description:

P07550

Residue:

413

Sequence:

MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL

BDBM50318160

n/a

Name

BDBM50318160

Synonyms:

8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-ylamino)-ethyl]-1H-quinolin-2-one | CHEMBL1094483

Type

Small organic molecule

Emp. Form.

C22H24N2O3

Mol. Mass.

364.4376

SMILES

Cc1cc2CC(Cc2cc1C)NC[C@H](O)c1ccc(O)c2[nH]c(=O)ccc12 |r|

Structure