Ki Summary

Reaction Details

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Target

Prostaglandin E2 receptor EP4 subtype

Ligand

BDBM50318871

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_633616 (CHEMBL1117759)

EC50

1.6±n/a nM

Citation

Allen, JG; Fotsch, C; Babij, P Emerging targets in osteoporosis disease modification. J Med Chem53:4332-53 (2010) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prostaglandin E2 receptor EP4 subtype

Name:

Prostaglandin E2 receptor EP4 subtype

Synonyms:

PE2R4_MOUSE | PGE receptor, EP4 subtype | Prostanoid EP4 receptor | Ptger4 | Ptgerep4

Type:

G-protein coupled receptor

Mol. Mass.:

56175.66

Organism:

Mus musculus (Mouse)

Description:

n/a

Residue:

513

Sequence:

MAEVGGTIPRSNRELQRCVLLTTTIMSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGN
LVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYS
TFILLFFGLSGLSIICAMSIERYLAINHAYFYSHYVDKRLAGLTLFAIYASNVLFCALPN
MGLGRSERQYPGTWCFIDWTTNVTAYAAFSYMYAGFSSFLILATVLCNVLVCGALLRMHR
QFMRRTSLGTEQHHAAAAAAVASVACRGHAGASPALQRLSDFRRRRSFRRIAGAEIQMVI
LLIATSLVVLICSIPLVVRVFINQLYQPNVVKDISRNPDLQAIRIASVNPILDPWIYILL
RKTVLSKAIEKIKCLFCRIGGSGRDSSAQHCSESRRTSSAMSGHSRSFLARELKEISSTS
QTLLYLPDLTESSLGGRNLLPGSHGMGLTQADTTSLRTLRISETSDSSQGQDSESVLLVD
EVSGSHREEPASKGNSLQVTFPSETLKLSEKCI

BDBM50318871

n/a

Name

BDBM50318871

Synonyms:

4-(2-{(1R,2R,3R)-3-Hydroxy-2-[(E)-(S)-3-hydroxy-4-(3-methoxymethyl-phenyl)-but-1-enyl]-5-oxo-cyclopentyl}-ethylsulfanyl)-butyric acid methyl ester | CHEMBL303960 | methyl 4-(2-((1R,2R,3R)-3-hydroxy-2-((S,E)-3-hydroxy-4-(3-(methoxymethyl)phenyl)but-1-enyl)-5-oxocyclopentyl)ethylthio)butanoate

Type

Small organic molecule

Emp. Form.

C24H34O6S

Mol. Mass.

450.588

SMILES

COCc1cccc(C[C@H](O)\C=C\[C@H]2[C@H](O)CC(=O)[C@@H]2CCSCCCC(=O)OC)c1 |r|

Structure