| Reaction Details |
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 | Report a problem with these data |
| Target | Hydroxycarboxylic acid receptor 2 |
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| Ligand | BDBM50319109 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_635632 (CHEMBL1119082) |
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| IC50 | 4±n/a nM |
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| Citation |  Schmidt, D; Smenton, A; Raghavan, S; Shen, H; Ding, FX; Carballo-Jane, E; Luell, S; Ciecko, T; Holt, TG; Wolff, M; Taggart, A; Wilsie, L; Krsmanovic, M; Ren, N; Blom, D; Cheng, K; McCann, PE; Waters, MG; Tata, J; Colletti, S Anthranilic acid replacements in a niacin receptor agonist. Bioorg Med Chem Lett20:3426-30 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hydroxycarboxylic acid receptor 2 |
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| Name: | Hydroxycarboxylic acid receptor 2 |
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| Synonyms: | G-protein coupled receptor 109A | G-protein coupled receptor HM74A | GPR109A | HCA2 | HCAR2 | HCAR2_HUMAN | HM74A | Hydroxycarboxylic acid receptor 2 | NIACR1 | Niacin Receptor GPR109A | Nicotinic acid receptor 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 41868.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO cells expressing the recombinant human GPR109A were used in competition binding assay. |
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| Residue: | 363 |
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| Sequence: | MNRHHLQDHFLEIDKKNCCVFRDDFIVKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWK
SSRIFLFNLAVADFLLIICLPFLMDNYVRRWDWKFGDIPCRLMLFMLAMNRQGSIIFLTV
VAVDRYFRVVHPHHALNKISNRTAAIISCLLWGITIGLTVHLLKKKMPIQNGGANLCSSF
SICHTFQWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVF
VICFLPSVVVRIRIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPS
FPNFFSTLINRCLQRKMTGEPDNNRSTSVELTGDPNKTRGAPEALMANSGEPWSPSYLGP
TSP
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| BDBM50319109 |
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| n/a |
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| Name | BDBM50319109 |
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| Synonyms: | 2-(3-(3-(5-hydroxypyridin-2-yl)-1,2,4-oxadiazol-5-yl)propanamido)-5-propylcyclohex-1-enecarboxylic acid | CHEMBL1084576 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H24N4O5 |
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| Mol. Mass. | 400.4284 |
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| SMILES | CCCC1CCC(NC(=O)CCc2nc(no2)-c2ccc(O)cn2)=C(C1)C(O)=O |c:25| |
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| Structure | 
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