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TargetDual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
LigandBDBM50319163
Substrate/Competitorn/a
Meas. Tech.ChEMBL_635693 (CHEMBL1120091)
IC50 69±n/a nM
Citation Höfgen, NStange, HSchindler, RLankau, HJGrunwald, CLangen, BEgerland, UTremmel, PPangalos, MNMarquis, KLHage, THarrison, BLMalamas, MSBrandon, NJKronbach, T Discovery of imidazo[1,5-a]pyrido[3,2-e]pyrazines as a new class of phosphodiesterase 10A inhibitiors. J Med Chem53:4399-411 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Name:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A
Synonyms:Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A | PDE11A | PDE11_HUMAN | Phosphodiesterase 11 | Phosphodiesterase 11A | Phosphodiesterase 11A (PDE11A4) | Phosphodiesterase 11A4 | cAMP and cGMP phosphodiesterase 11A
Type:Enzyme
Mol. Mass.:104751.53
Organism:Homo sapiens (Human)
Description:Q9HCR9
Residue:933
Sequence:
MAASRLDFGEVETFLDRHPELFEDYLMRKGKQEMVEKWLQRHSQGQGALGPRPSLAGTSS
LAHSTCRGGSSVGGGTGPNGSAHSQPLPGGGDCGGVPLSPSWAGGSRGDGNLQRRASQKE
LRKSFARSKAIHVNRTYDEQVTSRAQEPLSSVRRRALLRKASSLPPTTAHILSALLESRV
NLPRYPPTAIDYKCHLKKHNERQFFLELVKDISNDLDLTSLSYKILIFVCLMVDADRCSL
FLVEGAAAGKKTLVSKFFDVHAGTPLLPCSSTENSNEVQVPWGKGIIGYVGEHGETVNIP
DAYQDRRFNDEIDKLTGYKTKSLLCMPIRSSDGEIIGVAQAINKIPEGAPFTEDDEKVMQ
MYLPFCGIAISNAQLFAASRKEYERSRALLEVVNDLFEEQTDLEKIVKKIMHRAQTLLKC
ERCSVLLLEDIESPVVKFTKSFELMSPKCSADAENSFKESMEKSSYSDWLINNSIAELVA
STGLPVNISDAYQDPRFDAEADQISGFHIRSVLCVPIWNSNHQIIGVAQVLNRLDGKPFD
DADQRLFEAFVIFCGLGINNTIMYDQVKKSWAKQSVALDVLSYHATCSKAEVDKFKAANI
PLVSELAIDDIHFDDFSLDVDAMITAALRMFMELGMVQKFKIDYETLCRWLLTVRKNYRM
VLYHNWRHAFNVCQLMFAMLTTAGFQDILTEVEILAVIVGCLCHDLDHRGTNNAFQAKSG
SALAQLYGTSATLEHHHFNHAVMILQSEGHNIFANLSSKEYSDLMQLLKQSILATDLTLY
FERRTEFFELVSKGEYDWNIKNHRDIFRSMLMTACDLGAVTKPWEISRQVAELVTSEFFE
QGDRERLELKLTPSAIFDRNRKDELPRLQLEWIDSICMPLYQALVKVNVKLKPMLDSVAT
NRSKWEELHQKRLLASTASSSPASVMVAKEDRN
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50319163
n/a
NameBDBM50319163
Synonyms:8-Methoxy-3-methyl-4-methylsulfonylamino-1-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine | CHEMBL1085374
TypeSmall organic molecule
Emp. Form.C15H19N5O3S
Mol. Mass.349.408
SMILESCCCc1nc(C)c2c(NS(C)(=O)=O)nc3ccc(OC)nc3n12
Structure
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