| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 1 |
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| Ligand | BDBM50319227 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633815 (CHEMBL1119893) |
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| IC50 | 9700±n/a nM |
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| Citation |  Wang, H; Lim, ZY; Zhou, Y; Ng, M; Lu, T; Lee, K; Sangthongpitag, K; Goh, KC; Wang, X; Wu, X; Khng, HH; Goh, SK; Ong, WC; Bonday, Z; Sun, ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett20:3314-21 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 1 |
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| Name: | Histone deacetylase 1 |
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| Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 55090.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13547 |
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| Residue: | 482 |
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| Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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| BDBM50319227 |
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| n/a |
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| Name | BDBM50319227 |
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| Synonyms: | 6-[3-(1-Phenethyl-1H-benzimidazole-5-carbonyl)-ureido]-hexanoic acid hydroxyamide | CHEMBL1086548 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H27N5O4 |
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| Mol. Mass. | 437.4916 |
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| SMILES | ONC(=O)CCCCCNC(=O)NC(=O)c1ccc2n(CCc3ccccc3)cnc2c1 |
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| Structure | 
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