| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3 |
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| Ligand | BDBM50319209 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_633818 |
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| Ki | 8±n/a nM |
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| Citation |  Wang H; Lim ZY; Zhou Y; Ng M; Lu T; Lee K; Sangthongpitag K; Goh KC; Wang X; Wu X; Khng HH; Goh SK; Ong WC; Bonday Z; Sun ET Acylurea connected straight chain hydroxamates as novel histone deacetylase inhibitors: Synthesis, SAR, and in vivo antitumor activity. Bioorg Med Chem Lett 20:3314-21 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3 |
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| Name: | Histone deacetylase 1/2/3 |
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| Synonyms: | HD3 | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| BDBM50319209 |
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| n/a |
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| Name | BDBM50319209 |
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| Synonyms: | 6-[3-(4-Bromo-benzoyl)-ureido]-hexanoic acid hydroxyamide | CHEMBL1083086 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H18BrN3O4 |
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| Mol. Mass. | 372.214 |
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| SMILES | ONC(=O)CCCCCNC(=O)NC(=O)c1ccc(Br)cc1 |
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| Structure | 
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